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If you just using the E3D machine in single tool type mode without a wiper then the initial prime would be in the startup Gcode section of machine...
alternat spool holder with a removable shaft. makes it possible to change the spool with the bed in the way.
here is the wiper I'm using. Grab a silicone sheet from mcmaster https://www.mcmaster.com/5787t33 you'll also need a 3x~8mm bolt to clamp the...
Cura does this.
If you haven't already, check the grub screws on the drive pulleys. I had wavy surfaces and it had me scratching my head until one pully let go...