I feel like I have my S3D profile nailed for PLA now. If you do decide to use my profile, your first layer is still always going to come down to the bed levelling process and your flow control. I personally don't seem to grasp the filament esteps calibration, so I'm calibrating flow by watching like a hawk as the first layer goes down. I had to unlearn quite a bit to get here. This printer is not my old printer. I tried all sort of retraction options on the way to this, but noticed the benchies people were posting on G+ were better than mine. I'd struggled with the first benchy, likely due to differences in the fan positioning, the fan effectiveness, and possibly even my heater effectiveness. I just died almost on layer 5 to 7. So I'd then turned to S3D and used knowledge learned on another printer, with lots of fairly horrible results. Eventually I decided to open up the supplied benchy gcode and see how it had been sliced (handily printed into the file at the top by S3D). I began setting up my profile like theirs, and noticed they don't ever lift on retraction. The speed of movement of the carriage, plus a little retraction of filament seemed to be enough. I also noted they had accepted that the best overall shell comes from giving in to having a seam somewhere. FYI when slicing with my profile, the seam position is set on the far right of the bed in the center, so if it's important to you, re-orient your model so the seam will be on the at the right most point. Alas, I tweak the profile all the time, so can't 100% guarantee it, but these two should be almost identical to the one that printed this, and I've created one for printing with each of the extruders on a dual (still yet to figure out running them both on the same print. If yours is a pro or lite, you only need to alter the machine dimensions to open up the rest of your bed. I hope this helps someone.