Not sure if this concerns the BigBox profile for S3D since I don't have my Box yet. But I had a chance to learn more about S3D in the past days and weeks. One of the things that annoyed me was that the parts cooling fan did not stop after the last drop of filament has been extruded. Slic3r switches the fan off after everything has been done, S3D does not. A quick look into the g-code shows that the parts cooler is controlled by the M106 Sxxx command. xxx takes values between 000 and 255, Adding the command line M106 S0 to the end-of-job script in the profile takes care of that. This revealed another user-unfriendly weakness of the program - if you change such a global parameter that is valid for all configurations and combinations, you have to do that in each and every profile separately. Slic3r has separate configuration files for the printer itself (where you define its geometry and global technical parameters), filament (including temperature control) and the printing process itself where you define layer thicknesses, speed and other dynamic and object-related data. S3D lacks that. Back to the lab, would be my advice.