I left my printer unattended and came back to find a blob of plastic encasing my hot end. When I removed the plastic it remo removed the wires to the thermistor. The screw is filled with plastic, so I am unable to remove the thermistor in order to replace it. Any tips on how to fix my issue?
Replace the heater block and thermistor? You could also try removing the heater block, then heating it sufficiently (boiling water may be sufficient) to soften the PLA so that you can get the screw out.
Tend to agree with dc42 as whatever you do, solvent, hot water, blowtorch is going to be messy and take time. Assuming the heat-break and heat-sink are good, (I'm probably wrong in assuming a V6 from E3D) and the thermistor is kaput anyway then it's the block and the nozzle to replace. It will also be one hell of a job removing the plastic from the grub screw so you will need a new one too. If you have time and patience then I think a nasty solvent is probably best and getting high on the fumes will take your mind of it not working. Kidding about the solvents effects, should be done in a well ventilated room or even outside as this kind of stuff is usually highly flammable too.